BDBM50420698 CHEMBL2087082

SMILES CCONC(=O)c1ccc2[nH]ncc2c1Nc1ccc(I)cc1F

InChI Key InChIKey=BEYHNMFRDWRJGB-UHFFFAOYSA-N

Data  1 IC50  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420698   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420698(CHEMBL2087082)Copy SMILESCopy InChI

Affinity DataIC50: 93nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420698(CHEMBL2087082)Copy SMILESCopy InChI

Affinity DataEC50:  1.30nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420698(CHEMBL2087082)Copy SMILESCopy InChI

Affinity DataEC50:  2.40nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL