BDBM50420697 CHEMBL2087081

SMILES Fc1cc(I)ccc1Nc1c(ccc2[nH]ncc12)C(=O)NOCC1CC1

InChI Key InChIKey=DDHMFHZVMCWHNC-UHFFFAOYSA-N

Data  1 IC50  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50420697   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420697(CHEMBL2087081)Copy SMILESCopy InChI

Affinity DataIC50: 79nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420697(CHEMBL2087081)Copy SMILESCopy InChI

Affinity DataEC50:  1.5nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

LigandBDBM50420697(CHEMBL2087081)Copy SMILESCopy InChI

Affinity DataEC50:  1.5nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL