BDBM50420315 CHEMBL2089106

SMILES Cc1nc(=O)c2sc(nc2n1Cc1cccc(c1C)C(F)(F)F)N1CCOCC1

InChI Key InChIKey=REVHYTKYLAMCJQ-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50420315   

LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  24nMAssay Description:Inhibition of PI3K beta in human PTEN-deficient MDA-MB-468 cells assessed as inhibition of Akt Ser473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50: 790nMAssay Description:Inhibition of PI3K gamma by continuous TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI3K delta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3K beta by continuous TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of PI3K alpha by continuous TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  16nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in presence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataEC50:  6.30nMAssay Description:Inhibition of PI3Kbeta human in PTEN-null MDA-MB-468 cells assessed as reduction of AKT phosphorylation at Ser 473 in absence of serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50420315(CHEMBL2089106)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed