BDBM50419436 CHEMBL1915747::US9138494, JNJ-41510417

SMILES FCCn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=OKSASUFSNRSZFA-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50419436   

LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50: 0.630nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected insect Sf9 cells using [3H]cAMP as substrate after 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to full length human PDE10A assessed as dissociation constant using [3H]-cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50419436(CHEMBL1915747 | US9138494, JNJ-41510417)
Affinity DataKd:  6.60nMAssay Description:Binding affinity to full length human PDE10A assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed