BDBM50417275 CHEMBL1271939

SMILES CN1[C@@H](CN(C1=O)c1cccnc1C)C(=O)NCc1ccc(Cl)cc1Cl

InChI Key InChIKey=ICWRCRSAONKLSI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50417275   

TargetP2X purinoceptor 7(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417275(CHEMBL1271939)
Affinity DataIC50: 63.1nMAssay Description:Antagonist activity at rat recombinant P2X7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417275(CHEMBL1271939)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417275(CHEMBL1271939)
Affinity DataIC50: 10nMAssay Description:Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation preincubated with compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed