BDBM50415790 CHEMBL1093774::GSK-1564023A::US10272074, Example 115

SMILES Cc1noc(C)c1-c1ccc(CNC(=O)c2cnc3n(C)nc(C)c3c2Cl)cc1

InChI Key InChIKey=QWZQPWUWGYGVOC-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50415790   

TargetGlucocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of cortisol-induced renilla luciferase transactiv...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataEC50: >6.31E+3nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as renilla luciferase transactivation activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataIC50: 2.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cells assessed as inhibition of aldosterone-induced eff...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMineralocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataEC50: >2.00E+4nMAssay Description:Antagonist activity at human mineralocorticoid receptor expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataIC50: 3.16E+3nMAssay Description:Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells assessed as inhibition of progesterone-induced effec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProgesterone receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human PDE4B by ATP-luciferace luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlucocorticoid receptor(Human)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50415790(GSK-1564023A | CHEMBL1093774 | US10272074, Example...)
Affinity DataIC50: 275nMAssay Description:The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...More data for this Ligand-Target Pair
In DepthDetails
US Patent