BDBM50404663 CHEMBL6885::QUINAZOLINE-2,4,6-TRIAMINE

SMILES Nc1ccc2nc(N)nc(N)c2c1

InChI Key InChIKey=LJBWEZVYRBKOCI-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50404663   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50404663(QUINAZOLINE-2,4,6-TRIAMINE | CHEMBL6885)
Affinity DataKd:  8.40E+4nMAssay Description:Binding affinity to Leishmania major DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetPteridine reductase 1(Leishmania major)
Universidad Nacional Aut£Noma De M£Xico

Curated by ChEMBL
LigandPNGBDBM50404663(QUINAZOLINE-2,4,6-TRIAMINE | CHEMBL6885)
Affinity DataKd:  5.88E+4nMAssay Description:Binding affinity to Leishmania major pteridine reductase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50404663(QUINAZOLINE-2,4,6-TRIAMINE | CHEMBL6885)
Affinity DataIC50: 2.69E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed