BDBM50402339 CHEMBL2206666

SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nccn3n2)c1

InChI Key InChIKey=BRFOGQVFBWDQGX-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50402339   

TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 49nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 60 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 35nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1-R by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of insulin receptor by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Tie-2 by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta using [gamma-33P]ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 290nMAssay Description:Inhibition of B-raf using [gamma-33P]ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 120nMAssay Description:Inhibition of c-Kit by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR4 using FGFR4 and ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of FGFR3 by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of FGFR1 by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 15nMAssay Description:Inhibition of PDGFRbeta by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 13nMAssay Description:Inhibition of PDGFRalpha by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of VEGFR1 by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402339(CHEMBL2206666)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human VEGFR2 for 5 mins prior to addition of 10 uM ATP using poly-GluTyr by AlphaScreen analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed