BDBM50401323 CHEMBL2205230

SMILES CCc1cc2n(C)c(C(=O)NC3CCN(CC3)C(=O)CO)c(OCC(F)(F)F)c2c(=O)n1CC(=O)c1ccccc1

InChI Key InChIKey=ZADWXQMNNVICKB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50401323   

TargetSonic hedgehog protein(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401323(CHEMBL2205230)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50401323(CHEMBL2205230)
Affinity DataIC50: 79nMAssay Description:Inhibition of Smo D473H mutant (unknown origin) expressed in mouse NIH3T3 cells cotransfected with Gli luciferase reporter gene assessed as Gli lucif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed