BDBM50400778 CHEMBL2204995
SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccnc(c1)N1CCN(C)CC1
InChI Key InChIKey=ULNXAWLQFZMIHX-UHFFFAOYSA-N
Data 20 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50400778
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PRMT1 using histone H4 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNMT1 using polydi-dc as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNMT3a using lambda DNA as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse DNMT3b1 using lambda DNA as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DOT1L using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of G9a using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLL2 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLL3 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLL4 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of PRMT4 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PRMT5 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of SET7 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SETMAR using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+5nMAssay Description:Inhibition of SUV39H2 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Human)
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 174nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MLL1 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair