BDBM50400600 CHEMBL2206277

SMILES CN1C(C)(C)CC(CC1(C)C)Oc1ccc(nc1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1

InChI Key InChIKey=INOASWZOZPQAQM-UHFFFAOYSA-N

Data  10 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50400600   

TargetCytochrome P450 2C9(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of PDGFRbeta phosphorylation in human MG63 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to PDGFRbeta expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to PDGFRalpha expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 8nMAssay Description:Inhibition of KIT phosphorylation in human H526 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to KIT expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 phosphorylation in human MV4-11 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 15nMAssay Description:Inhibition of M-CSF-induced FK506 -fussed CSF1R phosphorylation expressed in HEK293 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 50.4nMAssay Description:Inhibition of CSF1R in mouse M-NFS-60 cells assessed as inhibition of cell proliferation after 72 hrs by Celltiter-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataKd:  1nMAssay Description:Binding affinity to CSF1R expressed in HEK-293 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to FLT3 expressed in HEK-293 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50400600(CHEMBL2206277)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed