BDBM50399710 CHEMBL2178953

SMILES Cc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key InChIKey=YXFNPRHZMOGREC-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50399710   

TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT1 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 10nMAssay Description:Inhibition of DGAT1 in human HuTu80 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human DGAT2 by liquid scintillographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSterol O-acyltransferase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ACAT2 by liquid scintillographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 150nMAssay Description:Inhibition of DGAT1 in rat adipose tissue assessed as reduction in triacylglycerol synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 100nMAssay Description:Inhibition of DGAT1 in mouse liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 60nMAssay Description:Inhibition of DGAT1 in dog liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 8.05E+4nMAssay Description:Inhibition of muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of PDE10A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human ACAT1 by liquid scintillographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 90nMAssay Description:Inhibition of DGAT1 in rat adipose tissue assessed as reduction in triacylglycerol synthesisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 70nMAssay Description:Inhibition of DGAT1 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: 10nMAssay Description:Inhibition of DGAT1 in human HuTu80 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed