BDBM50399310 CHEMBL2180854

SMILES Brc1ccnc(NC(=O)Nc2cccc3C(=O)N4CCCCC4c23)c1

InChI Key InChIKey=GFPGWHOCRYTVLL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50399310   

TargetCyclin-dependent kinase 5 activator 1(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma-33P]-ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate and [gamma-33P]-ATP after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant CDK5/p25 using histone H1 as substrate in presence of [gamma-33P]ATP incubated for 30 mins by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 22nMAssay Description:Inhibition of native porcine brain GSK-3alpha/beta using GS-1 as substrate incubated for 30 mins in presence of [gamma-33P]ATP by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 25nMAssay Description:Binding affinity to CDK5 (unknown origin) assessed as change in gibbs free energyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50399310(CHEMBL2180854)
Affinity DataIC50: 22nMAssay Description:Binding affinity to GSK-3beta (unknown origin) assessed as change in gibbs free energyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed