BDBM50397745 CHEMBL2177161

SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1cccnc1

InChI Key InChIKey=FHCSBLWRGCOVPT-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50397745   

TargetGlycogen synthase kinase-3 beta(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataIC50: 76nMAssay Description:Inhibition of GSK3beta-mediated Tau phosphorylation in mouse 3T3 cells after 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataKon:  0.0193M-1s-1Assay Description:Binding affinity to recombinant GSK3beta (unknown origin) assessed as dissociation rate constant upto 0.00975 uM by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of recombinant human GSK-3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEE as substrate preincubated for 15 mins followed by substrate addition and...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataKi:  4.90nMAssay Description:Inhibition of human recombinant GSK3beta using biotin- AAEELDSRAGS(PO3H2)PQL as substrate and [gamma32P]ATP after 20 mins by scintillation proximity ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50397745(CHEMBL2177161)
Affinity DataKi:  4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed