BDBM50396623 CHEMBL2171923::US8765940, 1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran]

SMILES Cc1c(nc2cc(F)ccc2c1N1CC2(CCOCC2)c2ccc(cc12)N1CCOCC1)-c1ccccn1

InChI Key InChIKey=BREVOGJQDCKZGE-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50396623   

LigandPNGBDBM50396623(CHEMBL2171923 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataIC50: 143nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396623(CHEMBL2171923 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataIC50: 127nMAssay Description:Inhibition of PI3Kdelta in human B cells assessed as inhibition of anti-IgM/CD40L-induced proliferation after 72 hrs by [3H]thymidine incorporation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396623(CHEMBL2171923 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396623(CHEMBL2171923 | US8765940, 1-(7-fluoro-3-methyl-2-...)
Affinity DataKi:  18.2nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
Go to US Patent