BDBM50396622 CHEMBL2171921::US8765940, 1-(2,3-dimethyl-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran]

SMILES Cc1nc2ccccc2c(N2CC3(CCOCC3)c3ccc(cc23)N2CCOCC2)c1C

InChI Key InChIKey=RGAVJFDTYUBJAZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50396622   

LigandPNGBDBM50396622(CHEMBL2171921 | US8765940, 1-(2,3-dimethyl-4-quino...)
Affinity DataIC50: 450nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396622(CHEMBL2171921 | US8765940, 1-(2,3-dimethyl-4-quino...)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396622(CHEMBL2171921 | US8765940, 1-(2,3-dimethyl-4-quino...)
Affinity DataKi:  450nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
Go to US Patent