BDBM50396619 CHEMBL2171933::US8765940, 6-chloro-4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-2,3-dimethylquinoline

SMILES Cc1nc2ccc(Cl)cc2c(N2CC(C)(C)c3ccc(cc23)N2CCOCC2)c1C

InChI Key InChIKey=ZZMRFZSHBPPAOP-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50396619   

LigandPNGBDBM50396619(CHEMBL2171933 | US8765940, 6-chloro-4-(3,3-dimethy...)
Affinity DataIC50: 886nMAssay Description:Inhibition of PI3Kdelta in human B cells assessed as inhibition of anti-IgM/CD40L-induced proliferation after 72 hrs by [3H]thymidine incorporation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396619(CHEMBL2171933 | US8765940, 6-chloro-4-(3,3-dimethy...)
Affinity DataIC50: 626nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396619(CHEMBL2171933 | US8765940, 6-chloro-4-(3,3-dimethy...)
Affinity DataIC50: 60nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396619(CHEMBL2171933 | US8765940, 6-chloro-4-(3,3-dimethy...)
Affinity DataKi:  626nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
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