BDBM50396618 CHEMBL2171918::US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-dihydro-1H-indol-1-yl)-7-fluoro-3-methyl-2-(2-pyridinyl)quinoline

SMILES Cc1c(nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(cc12)N1CCOCC1)-c1ccccn1

InChI Key InChIKey=KSCBFWORETXFLG-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50396618   

LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 76nMAssay Description:Inhibition of PI3Kdelta in human B cells assessed as inhibition of anti-IgM/CD40L-induced proliferation after 72 hrs by [3H]thymidine incorporation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 58nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 53nMAssay Description:Inhibition of PI3Kbeta-mediated AKT Ser473 phosphorylation in human MDA-MB-468 cells after 120 mins by meso scale discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396618(CHEMBL2171918 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  30.2nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
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