BDBM50396040 CHEMBL1823895

SMILES COc1ccc(cc1OC)S(=O)(=O)N(Cc1ccc2OC(C)(C)C=Cc2c1)c1ccccc1

InChI Key InChIKey=IPZJNJPAVPZHJM-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50396040   

TargetHistone acetyltransferase p300(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataKd:  345nMAssay Description:Binding affinity to recombinant P300 CH1 domain assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of HIF1 transcriptional activity in human LN229 cells expressing VEGF-HRE-V6R and coexpressing luciferase, lac Z gene incubated for 1 hr i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataIC50: 593nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human LN229 cells expressing HRE-AP reporter gene preincubated for 1 hr under normoxia condition fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataIC50: 590nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed