BDBM50395076 CHEMBL2164243

SMILES CN(C)NC(=O)CCC(=O)O

InChI Key InChIKey=NOQGZXFMHARMLW-UHFFFAOYSA-N

Data  2 KI  16 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50395076   

TargetLysine-specific demethylase 7A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human KDM7A catalytic domain expressed in Escherichia coli by MALDI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProlyl 4-hydroxylase(PBCV-1)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 3.30E+6nMAssay Description:Inhibition of KDM4A (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4C(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 2.50E+6nMAssay Description:Inhibition of KDM4C (unknown origin) using H3K9me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 2.20E+6nMAssay Description:Inhibition of KDM5A (unknown origin) using H3K4me3 peptide and 2-oxoglutarate as substrate after 1 hr by FDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KDM2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLysine-specific demethylase 6A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant KDM6A after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone lysine demethylase PHF8(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 550nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysine-specific demethylase 4E(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 6B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human KDM6B catalytic domain expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human FIH expressed in Escherichia coli by MALDI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PHD2 expressed in Escherichia coli by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGamma-butyrobetaine dioxygenase(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human BBOX1 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli by formaldehyde dehydrogenase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataKi:  1.97E+3nMAssay Description:Competitive inhibition of human KDM2A expressed in Escherichia coli using 2-oxoglutarate by enzyme kinetic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataKi:  8.50E+4nMAssay Description:Mixed type inhibition of human KDM2A expressed in Escherichia coli assessed inhibition constant for compound-enzyme-substrate complex using methyl ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed