BDBM50394881 CHEMBL2165039::US8772480, 58

SMILES COc1ccc(Nc2ncccc2-c2nc(C)nc3nc[nH]c23)cn1

InChI Key InChIKey=YXRVSHHKBCULEI-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50394881   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataIC50: 292nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataKi:  12nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kgamma expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataKi:  45nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kbeta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataKi:  62nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataKi:  67nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kalpha expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394881(CHEMBL2165039 | US8772480, 58)
Affinity DataKi:  70nMAssay Description:Inhibition of human N-terminal poly-His tagged-PI3Kdelta expressed in Sf9 baculovirus system co-expressing p85alpha after 20 mins by AlphaScreen assa...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed