BDBM50394179 CHEMBL2158865

SMILES CNC(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1ccnc(Nc2ccc(Cl)c(c2)S(=O)(=O)N(C)C)n1

InChI Key InChIKey=LVHNHGTWHQOKPD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50394179   

TargetSerine/threonine-protein kinase SMG1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI3Kgamma using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 33nMAssay Description:Inhibition of PI3Kalpha using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 12nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394179(CHEMBL2158865)
Affinity DataIC50: 520nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed