BDBM50393342 CHEMBL2152252
SMILES CNC(=O)c1nc(cnc1N)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1cccc(F)c1F
InChI Key InChIKey=GEYLKEHPEKRUTC-UHFFFAOYSA-N
Data 30 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50393342
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Human)
Exelixis
Curated by ChEMBL
Exelixis
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CDK1/CyclinBMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Aurora kinase BMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Exelixis
Curated by ChEMBL
Exelixis
Curated by ChEMBL
Affinity DataIC50: 773nMAssay Description:Inhibition of human PI3Kgamma expressed in C5a-stimulated mouse RAW 264.7 cells assessed as inhibition of AKT phosphorylation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Platelet-derived growth factor subunit BMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Exelixis
Curated by ChEMBL
Exelixis
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CDC7More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 591nMAssay Description:Inhibition of human CYP2C9 using tolbutamide as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.33E+3nMAssay Description:Inhibition of human CYP2C8 using paclitaxel as substrate after 45 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP2C19 using mephenytoin as substrate after 45 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human CYP1A2 using phenacetin as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of human Erg expressed in CHO cells after 5 minsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Exelixis
Curated by ChEMBL
Exelixis
Curated by ChEMBL
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Exelixis
Curated by ChEMBL
Exelixis
Curated by ChEMBL
Affinity DataIC50: 435nMAssay Description:Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair