BDBM50393291 CHEMBL2140244

SMILES COc1cccc(CNc2nc(nnc2-c2ccccc2)-c2ccccn2)c1

InChI Key InChIKey=ILPKDJDZIKMYPJ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393291   

TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393291(CHEMBL2140244)
Affinity DataEC50:  4.15E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393291(CHEMBL2140244)
Affinity DataEC50:  6.27E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxia-inducible factor 1-alpha(Human)
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM50393291(CHEMBL2140244)
Affinity DataEC50:  3.92E+3nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed