BDBM50392122 CHEMBL2152633::US10874669, Compound (+)-10

SMILES CCCN(CCN1CCN(CC1)c1ccc2[nH]ccc2c1)[C@H]1CCc2nc(N)sc2C1

InChI Key InChIKey=YQJXEYCSOAXZLM-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50392122   

TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]spiroperidol from rat cloned dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataKi:  15.9nMAssay Description:A well established radioligand competition assay was carried out to evaluate binding affinity of the test compounds and were compared with that of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]spiroperidol from rat cloned dopamine D2L receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50392122(CHEMBL2152633 | US10874669, Compound (+)-10)
Affinity DataKi:  134nMAssay Description:A well established radioligand competition assay was carried out to evaluate binding affinity of the test compounds and were compared with that of th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent