BDBM50392111 CHEMBL2152613

SMILES c1ccc(cc1)CCOc2cccc(c2)Nc3ccccc3C(=O)N

InChI Key InChIKey=VVRUXFPJOVUDCV-UHFFFAOYSA-N

Data  18 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50392111   

TargetHistone deacetylase 8(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of sirtuin 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC11More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC10More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 7(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human recombinant SIRT3 using Fluor de Lys-SIRT as substrate incubated for 60 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed