BDBM50391363 CHEMBL2148074

SMILES Oc1ccc(Cl)cc1-c1c[nH]nn1

InChI Key InChIKey=NBDFMTBYKCBTSW-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50391363   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 90nMAssay Description:Inhibition of human IDO1 transfected in HEK293T cells assessed as kynurenine formation using L-Trp as substrate after 7 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 80nMAssay Description:Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by UV-visible spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in kynurenine production using L-tryptop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 110nMAssay Description:Inhibition of human IDO1 expressed in HEK293T cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 7 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli Rosetta (DE3) cells assessed as reduction in kynurenine production using L-tryptop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 53nMAssay Description:Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 82nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 53nMAssay Description:Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 82nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 80nMAssay Description:Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 90nMAssay Description:Inhibition of human IDO1 transfected in HEK293T cells assessed as kynurenine formation using L-Trp as substrate after 7 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Mouse)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of mouse IDO2 transfected in HEK293T cells assessed as kynurenine formation using L-Trp as substrate after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 2(Mouse)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of mouse IDO2 transfected in HEK293T cells assessed as kynurenine formation using L-Trp as substrate after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 71nMpH: 7.4Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 7.4 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sib Swiss Institute For Bioinformatics

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 330nMpH: 6.5Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50391363(CHEMBL2148074)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed