BDBM50389805 CHEMBL2070715

SMILES NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1cccc(c1)C#N

InChI Key InChIKey=RPNHMRQXEKXDFG-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50389805   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389805(CHEMBL2070715)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant CHK1 expressed in insect cells using biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR as substrate after 2 hrs by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389805(CHEMBL2070715)
Affinity DataEC50:  940nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as abrogation of camptothecin induced check pointMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50389805(CHEMBL2070715)
Affinity DataEC50: >1.30E+4nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as check point abrogationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed