BDBM50389730 CHEMBL2069946::US10172858, Table 2.7::US10544104, Compound 24::US10844067, Example 44::US11247972, Compound 24::US11661423, Example 44::US9765037, Compound 24::US9828378, # 7

SMILES CC(C)n1nc(-c2cc3ccccc3[nH]2)c2c(N)ncnc12

InChI Key InChIKey=SQZDJBNTERGDSI-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50389730   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 1.87E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 4.57E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 18.7nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 70.4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetcGMP-dependent protein kinase(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 11.9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 1.87E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 4.57E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 18.7nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 353nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 70.4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 11.9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110 /p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
Go to US Patent

TargetCytosolic arginine sensor for mTORC1 subunit 1(Human)
Intellikine

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 100nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110 /p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
Go to US Patent

TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 70.4nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 11.9nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Intellikine

US Patent
LigandPNGBDBM50389730(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Affinity DataIC50: 100nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent