BDBM50389698 CHEMBL2070065::US10544104, Compound 37::US11247972, Compound 37::US9765037, Compound 37

SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCc5ccccc5Cl)ccc4c3)c12

InChI Key InChIKey=ALIRNZFSPVRFPC-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50389698   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.30nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 0.800nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetcGMP-dependent protein kinase(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50389698(CHEMBL2070065 | US9765037, Compound 37 | US1054410...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent