BDBM50389154 CHEMBL2064666

SMILES COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1

InChI Key InChIKey=LAJAFFLJAJMYLK-UHFFFAOYSA-N

Data  29 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50389154   

TargetFocal adhesion kinase 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 133nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 88nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 48nMAssay Description:Inhibition of human Flt4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 60nMAssay Description:Inhibition of human GCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 112nMAssay Description:Inhibition of human JNK1alpha1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 61nMAssay Description:Inhibition of human Rsk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 13nMAssay Description:Inhibition of human Rsk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Rsk3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Rsk4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human ALK cytoplasmic domain expressed in baculovirus using GST-PLCgamma as substrate preincubated for 15 mins before substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ACK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 26nMAssay Description:Inhibition of human ARK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 6(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 73nMAssay Description:Inhibition of human BRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 29nMAssay Description:Inhibition of human CHK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fer(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 85nMAssay Description:Inhibition of human FerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 99nMAssay Description:Inhibition of human FesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human ALK expressed in baculovirus using recombinant GST PLC-gamma as substrate assessed as phosphorylation of the substrate after 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 25nMAssay Description:Inhibition of human FAK expressed in baculovirus after 30 mins using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 20nMAssay Description:Inhibition of NPM-ALK phosphorylation in human SUP-M2 cells after 2 to 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 662nMAssay Description:Inhibition of recombinant human INSR expressed in baculovirus using ATP as substrate after 15 mins by TRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 944nMAssay Description:Inhibition of FAK phosphorylation in human HCC827 cells after 2 to 2.5 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone/midazolam as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSR (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Teva Branded Pharmaceutical Products R & D

Curated by ChEMBL
LigandPNGBDBM50389154(CHEMBL2064666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed