BDBM50387726 CHEMBL2058878

SMILES NC(=N)SCc1cccc2c1oc1c(CSC(N)=N)cccc21

InChI Key InChIKey=DYFMZELGKHUTCS-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50387726   

TargetNatural resistance-associated macrophage protein 1(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NRAMP1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetNatural resistance-associated macrophage protein 2(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataIC50: 140nMAssay Description:Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNatural resistance-associated macrophage protein 2(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of human DMT1 expressed in HEK293T cells assessed as inhibition of radiolabeled 55Fe2+ uptake preincubated with compound for 5 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNatural resistance-associated macrophage protein 2(Human)
University of Bern

Curated by ChEMBL
LigandPNGBDBM50387726(CHEMBL2058878)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed