BDBM50387587 CHEMBL2057730::US8633204, 211

SMILES Cc1nc(N)nc2n(C3CC3)c(=O)c(cc12)-c1cn[nH]c1

InChI Key InChIKey=VJJRLZSQNXGZAK-UHFFFAOYSA-N

Data  2 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50387587   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pfizer

US Patent

LigandBDBM50387587(CHEMBL2057730 | US8633204, 211)Copy SMILESCopy InChI

Affinity DataIC50: 78nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/6/2014
Entry Details
Copy Entry DOIGo to US Patent

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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Mouse)
Pfizer

Curated by ChEMBL

LigandBDBM50387587(CHEMBL2057730 | US8633204, 211)Copy SMILESCopy InChI

Affinity DataKi:  36nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50387587(CHEMBL2057730 | US8633204, 211)Copy SMILESCopy InChI

Affinity DataKi:  190nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/8/2013
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL