BDBM50387330 CHEMBL2046643

SMILES CC(C)C[C@H]1CN(CCN1)c1ccc(c(n1)C(=O)c1cccnc1N)C(F)(F)F

InChI Key InChIKey=XWKJUHBICAMYNW-UHFFFAOYSA-N

Data  16 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50387330   

TargetProtein kinase C theta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 52nMAssay Description:Inhibition of PKCtheta-mediated IL-2 production by cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of FYNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of LYNMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of c-RafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C theta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  3nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C epsilon type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  17nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  37nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  76nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C beta type(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  260nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  580nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLysine--tRNA ligase(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PlkMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed