BDBM50386892 CHEMBL2048512::MMP inhibitor III

SMILES CNC(=O)C(CCc1ccccc1)NC(=O)C(CC(C)C)CC(=O)NO

InChI Key InChIKey=FQRZOEBSTPAQBJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50386892   

TargetInterstitial collagenase [100-268](Human)
East China University of Science and Technology

LigandPNGBDBM50386892(CHEMBL2048512 | MMP inhibitor III)
Affinity DataIC50: 10nMpH: 7.5Assay Description:The activity of cd-MMP-1 was measured using a fluorescence-based assay. It was performed in white 96-well half area microplate (Greiner) in a final v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50386892(CHEMBL2048512 | MMP inhibitor III)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human recombinant MMP12 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50386892(CHEMBL2048512 | MMP inhibitor III)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant MMP13 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50386892(CHEMBL2048512 | MMP inhibitor III)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human recombinant MMP1 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50386892(CHEMBL2048512 | MMP inhibitor III)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human recombinant MMP2 catalytic domain incubated for 20 mins by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed