BDBM50386486 CHEMBL2048063

SMILES CC(C)(C)Cc1cc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)no1

InChI Key InChIKey=JMAIWRCWOGUIRQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50386486   

TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50386486(CHEMBL2048063)
Affinity DataIC50: 470nMAssay Description:Inhibition of BACE-1 mediated amyloid beta 40 release in human wild type APP-transfected CHO cells by HTRF immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50386486(CHEMBL2048063)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant BACE1 ectodomain after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCathepsin D(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50386486(CHEMBL2048063)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant CatD using Mca-GKPILFFRLK(DNP)-dR-NH2 as substrate after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50386486(CHEMBL2048063)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed