BDBM50385309 CHEMBL2035983
SMILES C[C@]1(CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2C[C@]3(Cc2c1)C(=O)Nc1ncccc31)c1cc(F)cc(F)c1
InChI Key InChIKey=IDKKNSOZWQOAAS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50385309
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the absence...More data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at human CGRP receptor expressed in HEK293 cells assessed as inhibition of CGRP-induced cAMP response after 5 mins in the presenc...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NaV1.5 ion channel by voltage clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E member 1(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Iks ion channel by voltage clamp assayMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CaV1.2 ion channel by voltage clamp assayMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0470nMAssay Description:Displacement of [125I]CGRP from human recombinant CALCRL/RAMP1 receptor expressed in HEK293 cells after 3 hrsMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0520nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in human SK-N-MC cells after 3 hrsMore data for this Ligand-Target Pair
TargetIsoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 1(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Displacement of [125I]amylin from human AMY1 receptor expressed in COS7 cells after 3 hrsMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Rat)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Displacement of [125I]CGRP from CGRP receptor in rat brain membrane after 3 hrsMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor(Mouse)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [125I]CGRP from mouse CGRP receptorMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 3(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 590nMAssay Description:Displacement of [125I]adrenomedullin from human AM2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetIsoform 1 of Calcitonin receptor (1)/Receptor activity-modifying protein 3(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Displacement of [125I]amylin from human AMY3 receptor expressed in COS7 cells after 3 hrsMore data for this Ligand-Target Pair
Affinity DataKi: 3.20E+3nMAssay Description:Displacement of [125I]calcitonin from human CT receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 2(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of [125I]adrenomedullin from human AM1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair