BDBM50384789 CHEMBL2037378::Laccaic acid A (LCA)

SMILES CC(=O)NCCc1ccc(O)c(c1)-c1c(O)c(O)c2C(=O)c3cc(O)c(C(O)=O)c(C(O)=O)c3C(=O)c2c1O

InChI Key InChIKey=IHLWXZNPOVMUFQ-UHFFFAOYSA-N

Data  1 KI  7 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50384789   

LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 650nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 1.91E+4nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 2.78E+4nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 5.05E+4nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
TargetOrphan methyltransferase M.SssI(Spiroplasma monobiae strain MQ-1)
University of Iowa

LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 5.36E+4nMpH: 7.5Assay Description:Assays (0.1 ml) were conducted in 96-well black half-area plates in either a Wallac VICTOR2 or Biotek Synergy Neo plate reader at 37 °C in 10 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2017
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataEC50:  390nMAssay Description:Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataEC50:  5.15E+4nMAssay Description:Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactama...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetG-protein coupled receptor 35(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 390nMAssay Description:Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of HIV-1 RNase H using 5'-GAUCUGAGCCUGGGAGCU-3'-FAM RNA/BHQ-5'-AGCTCCCAGGCTCAGATC-3' DNA as substrate measured after 60 mins by FRET analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Chiba University

Curated by ChEMBL
LigandPNGBDBM50384789(CHEMBL2037378 | Laccaic acid A (LCA))
Affinity DataKi:  300nMAssay Description:Competitive inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed