BDBM50384727 CHEMBL2037226

SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1

InChI Key InChIKey=YYDUWLSETXNJJT-UHFFFAOYSA-N

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50384727   

LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Tel-fused FLT3 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 45nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant TRKA G667C mutant (440 to end residues) expressed in baculovirus infected Sf9 insect cells incu...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 320nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant TRKA G595R mutant (440 to end residues) expressed in baculovirus infected Sf9 insect cells incu...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of Tel-fused ROS in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 8nMAssay Description:Inhibition of TRKA by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 12nMAssay Description:Inhibition of TRKB by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of Tel-fused ALK in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of Tel-fused BMX in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 3(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Tel-fused EPHA3 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 2(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Tel-fused EPHB2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of Tel-fused FGFR3 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Tel-fused FGFR4 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fgr(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of Tel-fused FGR in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Tel-fused FLT1 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Tel-fused INSR in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Tel-fused FMS in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of Tel-fused IGF1R in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 9(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of Tel-fused JNK2 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 910nMAssay Description:Inhibition of Tel-fused KIT in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHepatocyte growth factor receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Tel-fused MET in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Lyn(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of Tel-fused LYN in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 870nMAssay Description:Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of Tel-fused RET in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of Tel-fused RON in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of Tel-fused SRC in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of Tel-fused TIE1 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of Tel-fused ZAP70 in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384727(CHEMBL2037226)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of c-Kit in human Mo7e cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed