BDBM50382358 CHEMBL324091

SMILES Nc1cc(F)ccc1Sc1ccc2c(-c3c(Cl)cccc3Cl)c(=O)ncn2n1

InChI Key InChIKey=AGCOATSSMCKBMC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50382358   

LigandPNGBDBM50382358(CHEMBL324091)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382358(CHEMBL324091)
Affinity DataIC50: 220nMAssay Description:Inhibition of p38alpha kinase using KRELVEPLTPSGEAPNQALLR as substrate for 20 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50382358(CHEMBL324091)
Affinity DataIC50: 280nMAssay Description:Inhibition of p38alpha in human PBMC assessed as inhibition of LPS-induced IL1beta production after 16 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50382358(CHEMBL324091)
Affinity DataIC50: 220nMAssay Description:Binding affinity against p38 MAP kinase systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed