BDBM50382016 CHEMBL2022374

SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cc(F)cc(F)c2)c1

InChI Key InChIKey=XYVHEZGROKPBMY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50382016   

TargetAurora kinase B(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50382016(CHEMBL2022374)
Affinity DataEC50:  2.38E+3nMAssay Description:Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50382016(CHEMBL2022374)
Affinity DataIC50: 94nMAssay Description:Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50382016(CHEMBL2022374)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed