BDBM50381996 CHEMBL2022373

SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1

InChI Key InChIKey=OPFNFKIYQOOQMS-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50381996   

TargetAurora kinase B(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataEC50:  58nMAssay Description:Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 20nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 481nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50381996(CHEMBL2022373)
Affinity DataIC50: 122nMAssay Description:Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed