BDBM50381980 CHEMBL2022495

SMILES COc1cc(NC(=O)c2ccccc2F)ccc1-c1nnc(NCCCN2CCCCC2)o1

InChI Key InChIKey=HXNBYYPGRZHDKJ-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50381980   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataEC50:  50.1nMAssay Description:Agonist activity at human alpha7 nAChR expressed in GH4C1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 5.01E+3nMAssay Description:Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 7.60E+4nMAssay Description:Inhibition of CYP3A4 using 7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAcetylcholine receptor subunit alpha(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 3.98E+3nMAssay Description:Antagonist activity at alpha1 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381980(CHEMBL2022495)
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed