BDBM50381284 CHEMBL2018876

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(cc1-[#8])-c1cc2ccc(-[#8])cc2o1

InChI Key InChIKey=KGHMDRNTZFKMBA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50381284   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human PDE5A1 catalytic domain (535 to 860) expressed in Escherichia coli BL21 using [3H]-cAMP/[3H]-cGMP after 15 mins by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 2.27E+3nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Dongguk University-Seoul

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 8.38E+4nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/7/2016
Entry Details Article
PubMed
TargetPancreatic triacylglycerol lipase(Pig)
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PDE9A2 catalytic domain (181 to 506) expressed in Escherichia coli BL21 using [3H]-cAMP/[3H]-cGMP after 15 mins by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413) expressed in Escherichia coli BL21 using [3H]-cAMP/[3H]-cGMP after 15 mins by liquid scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of human PDE4B2 catalytic domain and UCR2 (92 to 521) expressed in Escherichia coli BL21 using [3H]-cAMP/[3H]-cGMP after 15 mins by liquid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Nanchang University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 8.38E+4nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50381284(CHEMBL2018876)
Affinity DataIC50: 250nMAssay Description:Inhibition of XOD (unknown origin) using xanthine as substrate preincubated for 30 mins followed by xanthine addition measured after 30 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed