BDBM50380592 CHEMBL1552719

SMILES COc1ccc(cc1)-n1c(SCc2nc(no2)-c2ccc(C)cc2)nnc1-c1ccncc1

InChI Key InChIKey=KRIKILRRJCIWNB-UHFFFAOYSA-N

Data  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50380592   

TargetPoly [ADP-ribose] polymerase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of PARP1 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSulfotransferase 2A1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 50nMAssay Description:Inhibition of ST (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 650nMAssay Description:Inhibition of TNKS2 (unknown origin) using biotin-NAD+ as substrate at 5 uM incubated for 1 hr by ELISA relative to controlMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate at 3 uM incubated for 1 hr by ELISA relative to controlMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSteroidogenic factor 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 790nMAssay Description:Inhibition of Wnt in human HEK293 cells assessed as reduction in STF expression at 1 to 3 uM by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 650nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of PARP2 autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 460nMAssay Description:Inhibition of TNKS2 (unknown origin) by NAD+-dependent autopoly(ADP ribosyl)lation assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAxin-2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataEC50:  566nMAssay Description:Stabilization of Axin2 in human SW480 cells after 24 hrs by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 990nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein Wnt-3a(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 548nMAssay Description:Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 650nMAssay Description:Inhibition of GST-tagged TNKS2P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM50380592(CHEMBL1552719)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of GST-tagged TNKS1P catalytic domain autoPARsylation measuring nicotinamide concentration after 2 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed