BDBM50380447 CHEMBL2018772::N-{4-[7-(2-Diethylaminoethoxy)-6-methoxy-quinazolin-4-ylamino]phenyl}-N'-ethylurea hydrochloride (7i)

SMILES CCNC(=O)Nc1ccc(Nc2ncnc3cc(OCCN(CC)CC)c(OC)cc23)cc1

InChI Key InChIKey=OPURPEXJKOYZRK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50380447   

TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50380447(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Affinity DataIC50: 2.91E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50380447(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Affinity DataIC50: 4.03E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50380447(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Universit�� Lille Nord De France

LigandPNGBDBM50380447(CHEMBL2018772 | N-{4-[7-(2-Diethylaminoethoxy)-6-m...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed