BDBM50377181 CHEMBL256963::US11254667, Compound I-15::US11542261, Compound I-15

SMILES Clc1ccc2ncc(-c3cccc(NC4CNC4)n3)n2c1

InChI Key InChIKey=RDTAHMIMQLRAMR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50377181   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 1.95E+5nMAssay Description:Inhibition of IRAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 6nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGTPase NRas(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 1.66E+4nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 1.18E+3nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 45nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetGTPase NRas(Human)
Children''S Hospital Medical Center

US Patent
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 1.66E+4nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetDimer of Receptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandPNGBDBM50377181(CHEMBL256963 | US11254667, Compound I-15 | US11542...)
Affinity DataIC50: 1.18E+3nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent