BDBM50373415 CHEMBL256713

SMILES COc1cc(ccc1NC(=O)c1cccc(n1)-c1cc[nH]n1)N1CCOCC1

InChI Key InChIKey=RAFFLDOJXQAJPF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50373415   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50373415(CHEMBL256713)
Affinity DataIC50: 20nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50373415(CHEMBL256713)
Affinity DataIC50: 9nMAssay Description:Inhibition of wild-type human partial length IRAK1 (R194 to S712 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50373415(CHEMBL256713)
Affinity DataIC50: 17nMAssay Description:Inhibition of wild-type human partial length IRAK4 (M1 to S460 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50373415(CHEMBL256713)
Affinity DataIC50: 23nMAssay Description:Inhibition of truncated human N-terminal GST-fusion tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using FAM-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50373415(CHEMBL256713)
Affinity DataIC50: 24nMAssay Description:Inhibition of full length human N-terminal GST-fusion tagged IRAK4 expressed in baculovirus expression system using FAM-labelled peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed