BDBM50371783 CHEMBL397237

SMILES C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc2nc(N)sc12

InChI Key InChIKey=BDGUZDOTNGSANE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50371783   

TargetC-X-C chemokine receptor type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50: 4nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 cells by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50: 13nMAssay Description:Binding affinity to human CXCR2 expressed in human U87 cells assessed as inhibition of CXCL8 AF647-binding incubated for 15 mins followed by addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50: 79nMAssay Description:Binding affinity to human CXCR2 expressed in human U87 cells assessed as inhibition of CXCL8 AF647-induced calcium response incubated for 10 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed