BDBM50368977 CHEMBL4163069::US11124537, TABLE 3.31.1

SMILES [H][C@@]12CC[C@@](O)(C#CC(C)(C)C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C

InChI Key InChIKey=MKYOYWSMPLRHDW-UHFFFAOYSA-N

Data  13 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50368977   

TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at AR (unknown origin) expressed in human LNCaP cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at human androgen receptor in human LNCAP cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human progesterone receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of glucocorticoid receptor-dexamethasone coacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 129nMAssay Description:Antagonist activity at human androgen receptor in human LNCAP cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 8nMAssay Description:Displacement of fluormone tracer from full length human recombinant glucocorticoid receptor expressed in baculovirus expression system incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C8(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin) using paclitaxel as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 100nMAssay Description:Cell Line: CHO-K1-GR-MMTV-Luc reporter cellsCulture Media: DMEM (with phenol red)+10% FBSAssay Media: DMEM (without phenol red)+10% CSSCulture CHO-K1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 100nMAssay Description:Cell Line: CHO-K1-GR-MMTV-Luc reporter cellsCulture Media: DMEM (with phenol red)+10% FBSAssay Media: DMEM (without phenol red)+10% CSSCulture CHO-K1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)